| Rank | Title | Weekend | Gross |
|---|---|---|---|
| 1 | The Twilight Saga: Eclipse | $83.6M | $176M |
| 2 | The Last Airbender | $51.8M | $69.3M |
| 3 | Toy Story 3 | $43.1M | $302M |
| 4 | Grown Ups | $26.1M | $84.6M |
| 5 | Knight and Day | $14.2M | $49.5M |
| 6 | The Karate Kid | $11M | $155M |
| 7 | The A-Team | $4.4M | $70.5M |
| 8 | Get Him to the Greek | $1.72M | $58M |
| 9 | Shrek Forever After | $1.28M | $233M |
| 10 | Cyrus (2010/I) | $1.09M | $1.81M |